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In a blind random trial, (Lafuente) "examined 32 patients between the ages of 15 and 57. There were 25 women and 7 men randomly assigned to two groups. One group was given a placebo and received reflexology treatments two times a week for two or three months. The other group received Flunarizin treatment (a selective calcium entry blocker with calmodulin binding properties and histamine blocking activity that has been effective in preventing migraines) and massage of a non -specific area twice a week for 12 sessions. Patients were evaluated at the end of the study and again three months after the study. It was concluded that the reflexology treatment was at least as effective as the Flunarizin treatment and may be classified as an alternative non-pharmacological therapeutic treatment that would be particularly appropriate to those patients that were unable to follow pharmacological treatment."
Lafuente A et al (1990). Effekt der Reflex zonenbehandlung am FuB bezuglich der prophylaktischen Behandlung mit Flunarizin bei an Cephalea-Kopfschmerzen leidenden Patieten.Erfahrungsheilkunde. 39, 713-715.Testa, Gail W., "A Study on the Effects of Reflexology on Migraine Headaches" August 2000 (http://members.tripod.com/GTesta/Dissertationall.htm)